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1

Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

John W. Butcher, Nigel J. Liverton, Harold G. Selnick, Jason M. Elliot, Garry R. Smith, Andrew J. Tebben, David A. Pribush, John S. Wai, David A. Claremon

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 177 KB

english, 1996

2

Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist

Libby, Brian E., Liverton, Nigel J., Bednar, Rodney A., Bednar, Bohumil, Butcher, John W., Claiborne, Christopher F., Claremon, David A., Cunningham, Michael, DiLella, Anthony G., Gaul, Stanley L.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 194 KB

english, 2007

3

ChemInform Abstract: An Efficient Synthesis of Tetrasubstituted Imidazoles from N-(2-Oxo)-amides.

Christopher F. Claiborne, Nigel J. Liverton, Kevin T. Nguyen

Journal:

Year:

1999

File:

PDF, 32 KB

1999

4

ChemInform Abstract: Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase.

Nigel J. Liverton, et al. et al.

Journal:

Year:

1999

File:

PDF, 32 KB

1999

5

ChemInform Abstract: Chemoselective Reactions of Amidines: Selective Formation of Iminopyrimidine Regioisomers.

John A. McCauley, Cory R. Theberge, Nigel J. Liverton

Journal:

Year:

2001

File:

PDF, 30 KB

2001

6

ChemInform Abstract: Pyridazine Based Inhibitors of p38 MAPK.

Charles J. McIntyre, Gerald S. Ponticello, Nigel J. Liverton, Stephen J. O'Keefe, Edward A. O'Neill, Margaret Pang, Cheryl D. Schwartz, David A. Claremon

Journal:

Year:

2002

File:

PDF, 35 KB

2002

7

Synthesis of the first sulfur-35-labeled hERG radioligand

Conrad E. Raab, John W. Butcher, Thomas M. Connolly, Jerzy Karczewski, Nathan X. Yu, Steven J. Staskiewicz, Nigel Liverton, Dennis C. Dean, David G. Melillo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 124 KB

english, 2006

8

Phosphorous acid analogs of novel P2–P4 macrocycles as inhibitors of HCV–NS3 protease

Marco Pompei, Maria Emilia Di Francesco, Uwe Koch, Nigel J. Liverton, Vincenzo Summa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 763 KB

english, 2009

9

Kinetic characterization of novel NR2B antagonists using fluorescence detection of calcium flux

Bohumil Bednar, Michael E Cunningham, Laszlo Kiss, Gong Cheng, John A McCauley, Nigel J Liverton, Kenneth S Koblan

Journal:

Journal of Neuroscience Methods

Year:

2004

Language:

english

File:

PDF, 217 KB

english, 2004

10

An efficient synthesis of tetrasubstituted imidazoles from N-(2-Oxo)-amides

Christopher F. Claiborne, Nigel J. Liverton, Kevin T. Nguyen

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 154 KB

english, 1998

11

Pyridazine based inhibitors of p38 MAPK

Charles J McIntyre, Gerald S Ponticello, Nigel J Liverton, Stephen J O’Keefe, Edward A O’Neill, Margaret Pang, Cheryl D Schwartz, David A Claremon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 143 KB

english, 2002

12

Adenosine-2′-monophosphate derivatives: Structural requirements as substrates for inositol monophosphatase

Paul D. Leeson, Kim James, Ian C. Lennon, Nigel J. Liverton, Sue Aspley, Rosamond G. Jackson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 431 KB

english, 1993

13

Photochemical preparation of a pyridone containing tetracycle: A jak protein kinase inhibitor

James E. Thompson, Rose M. Cubbon, Richard T. Cummings, Linda S. Wicker, Robert Frankshun, Barry R. Cunningham, Patricia M. Cameron, Peter T. Meinke, Nigel Liverton, Youmin Weng, Julie A. DeMartino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 136 KB

english, 2002

14

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective IKs-blocking class III antiarrhythmic agents

John W Butcher, Nigel J Liverton, David A Claremon, Roger M Freidinger, Nancy K Jurkiewicz, Joseph J Lynch, Joseph J Salata, Jixin Wang, Christine M Dieckhaus, Donald E Slaughter, Kamlesh Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 148 KB

english, 2003

15

Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective IKs-Blocking Class III Antiarrhythmic Agents’: [Bioorg. Med. Chem. Lett. 13 (2003) 1165]

John W Butcher, Nigel J Liverton, David A Claremon, Roger M Freidinger, Nancy K Jurkiewicz, Joseph J Lynch, Joseph J Salata, Jixin Wang, Christine M Dieckhaus, Donald E Slaughter, Kamlesh Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 65 KB

english, 2003

16

Nonpeptide glycoprotein IIb/IIIa inhibitors: Substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists

Nigel J. Liverton, Donna J. Armstrong, David A. Claremon, David C. Remy, John J. Baldvin, Robert J. Lynch, Guixiang Zhang, Robert J. Gould

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 209 KB

english, 1998

17

MK-5172, a Novel Macrocyclic Inhibitor of NS3/4a Protease Demonstrates Efficacy Against Viral Resistance in the Chimpanzee Model of Chronic Hepatitis C Virus Infection

Steve Ludmerer, Steve Carroll, John McCauley, Mike Rudd, Paul Coleman, Nigel Liverton, Christine Burlein, Jill DiMuzio, Adam Gates, Don Graham, Carolyn McHale, Mark Stahlhut, Christine Fandozzi, Daria

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 64 KB

english, 2010

18

Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

Douglas C. Beshore, Nigel J. Liverton, Charles J. McIntyre, Christopher F. Claiborne, Brian Libby, J. Christopher Culberson, Joseph J. Salata, Christopher P. Regan, Joseph J. Lynch, Laszlo Kiss, Rober

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 407 KB

english, 2010

19

Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers

Rudd, Michael T., McIntyre, Charles J., Romano, Joseph J., Butcher, John W., Holloway, M. Katharine, Bush, Kimberly, Nguyen, Kevin T., Gilbert, Kevin F., Lyle, Terry A., Liverton, Nigel J., Wan, Bang-

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.24 MB

english, 2012

20

Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease

Liverton, Nigel J., Holloway, M. Katharine, McCauley, John A., Rudd, Michael T., Butcher, John W., Carroll, Steven S., DiMuzio, Jillian, Fandozzi, Christine, Gilbert, Kevin F., Mao, Shi-Shan, McIntyre

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 378 KB

english, 2008

21

Molecular Basis for p38 Protein Kinase Inhibitor Specificity

Lisnock, JeanMarie, Tebben, Andy, Frantz, Betsy, O'Neill, Edward A., Croft, Gist, O'Keefe, Stephen J., Li, Bing, Hacker, Candice, de Laszlo, Stephen, Smith, Anthony, Libby, Brian, Liverton, Nigel, Her

Journal:

Year:

1998

Language:

english

File:

PDF, 186 KB

english, 1998

22

Total synthesis of (+)-latrunculin A

Smith, Amos B., Noda, Ichio, Remiszewski, Stacy W., Liverton, Nigel J., Zibuck, Regina

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 310 KB

english, 1990

23

Design and synthesis of 6?-substituted 2?,4?-dihydroxy-1?-phosphoryloxycyclohexanes, potent inhibitors of inositol monophosphatase

Baker, Raymond, Carrick, Carmel, Leeson, Paul D., Lennon, Ian C., Liverton, Nigel J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1991

Language:

english

File:

PDF, 280 KB

english, 1991

24

Total synthesis of (+)-jatropholones A and B. Exploitation of the high-pressure technique

Smith, Amos B., Liverton, Nigel J., Hrib, Nicholas J., Sivaramakrishnan, Hariharan., Winzenberg, Kevin.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 1.29 MB

english, 1986

25

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by ( R )-2-(2,4- Trifluoromethyl)- N -[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1 H -benzo[ e ][1,4]diazepin-3-yl]acetamide

Selnick, Harold G., Liverton, Nigel J., Baldwin, John J., Butcher, John W., Claremon, David A., Elliott, Jason M., Freidinger, Roger M., King, Stella A., Libby, Brian E., McIntyre, Charles J., Pribush

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 100 KB

english, 1997

26

Total synthesis of the latrunculins

Smith, Amos B., Leahy, James W., Noda, Ichio, Remiszewski, Stacy W., Liverton, Nigel J., Zibuck, Regina

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 1.75 MB

english, 1992

27

Inhibitors of the Hepatitis C Virus NS3 Protease with Basic Amine Functionality at the P3-Amino Acid N-Terminus: Discovery and Optimization of a New Series of P2−P4 Macrocycles

Harper, Steven, Ferrara, Marco, Crescenzi, Benedetta, Pompei, Marco, Palumbi, Maria Cecilia, DiMuzio, Jillian M., Donghi, Monica, Fiore, Fabrizio, Koch, Uwe, Liverton, Nigel J., Pesci, Silvia, Petrocc

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 3.36 MB

english, 2009

28

General Photoisomerization Approach to trans-Benzobicyclo[5.1.0]octenes: Synthetic and Mechanistic Studies

Smith, Amos B., Wood, John L., Keenan, Terence P., Liverton, Nigel, Visnick, Melean

Journal:

Journal of Organic Chemistry

Year:

1994

Language:

english

File:

PDF, 3.95 MB

english, 1994

29

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Liverton, Nigel J., Butcher, John W., Claiborne, Christopher F., Claremon, David A., Libby, Brian E., Nguyen, Kevin T., Pitzenberger, Steven M., Selnick, Harold G., Smith, Garry R., Tebben, Andrew, Va

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 335 KB

english, 1999

30

An efficient photochemical approach to the trans-bicyclo[5.1.0]octene ring system

Wood, John L., Liverton, Nigel J., Visnick, Melean, Smith, Amos B.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 381 KB

english, 1989

31

Molecular Basis for p38 Protein Kinase Inhibitor Specificity

Lisnock, JeanMarie, Tebben, Andy, Frantz, Betsy, O'Neill, Edward A., Croft, Gist, O'Keefe, Stephen J., Li, Bing, Hacker, Candice, de Laszlo, Stephen, Smith, Anthony, Libby, Brian, Liverton, Nigel, Her

Journal:

Year:

1999

File:

PDF, 7 KB

1999

32

Correction. Total Synthesis of (+)-Latrunculin B

Zibuck, Regina., Liverton, Nigel J., Smith, Amos B.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 120 KB

english, 1986

33

Total synthesis of (+)-latrunculin B

Zibuck, Regina., Liverton, Nigel J., Smith, Amos B.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 384 KB

english, 1986

34

Total synthesis of (+)-jatropholone A and B

Smith, Amos B., Liverton, Nigel J., Hrib, Nicholas J., Sivaramakrishnan, Hariharan, Winzenberg, Kevin

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 426 KB

english, 1985

35

Chemoselective Reactions of Amidines: Selective Formation of Iminopyrimidine Regioisomers

McCauley, John A., Theberge, Cory R., Liverton, Nigel J.

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 41 KB

english, 2000

36

Synthesis of 2- and 6-deoxyinositol 1-phosphate and the role of the adjacent hydroxy groups in the mechanism of inositol monophosphatase

Baker, Raymond, Kulagowski, Janusz J., Billington, David C., Leeson, Paul D., Lennon, Ian C., Liverton, Nigel

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1989

Language:

english

File:

PDF, 340 KB

english, 1989

37

Identification of (1S)-phosphoryloxy-(2R,4S)-dihydroxycyclohexane as a potent inhibitor of inositol monophosphatase

Baker, Raymond, Leeson, Paul D., Liverton, Nigel J., Kulagowski, Janusz J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1990

Language:

english

File:

PDF, 280 KB

english, 1990

38

P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325

Rudd, Michael T., Butcher, John W., Nguyen, Kevin T., McIntyre, Charles J., Romano, Joseph J., Gilbert, Kevin F., Bush, Kimberly J., Liverton, Nigel J., Holloway, M. Katharine, Harper, Steven, Ferrara

Journal:

Year:

2015

Language:

english

File:

PDF, 791 KB

english, 2015

39

A total synthesis of zoapatanol

Cookson, Richard C., Liverton, Nigel J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1985

Language:

english

File:

PDF, 954 KB

english, 1985

40

Targeting the Metabotropic Glutamate Receptor mGluR4 for the Treatment of Diseases of the Central Nervous System

Marino, Michael, Hess, J., Liverton, Nigel

Journal:

Current Topics in Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 75 KB

english, 2005

41

In Vivo Cardiac Electrophysiologic and Antiarrhythmic Effects of an Isoquinoline IKur Blocker, ISQ-1, in Rat, Dog, and Nonhuman Primate

Regan, Christopher P, Stump, Gary L, Wallace, Audrey A, Anderson, Kenneth D, McIntyre, Charles J, Liverton, Nigel J, Lynch, Joseph J

Journal:

Journal of Cardiovascular Pharmacology

Year:

2007

Language:

english

File:

PDF, 369 KB

english, 2007

42

Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876

McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay,

Journal:

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

43

Front Cover: Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876 (ChemMedChem 17/2017)

McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay,

Journal:

Year:

2017

File:

PDF, 404 KB

2017

44

Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway

Ayala, Julia M., Goyal, Shefali, Liverton, Nigel J., Claremon, Dave A., O'Keefe, Stephen J., Hanlon, William A.

Journal:

Journal of Leukocyte Biology

Year:

2000

Language:

english

File:

PDF, 169 KB

english, 2000

45

[Topics in Medicinal Chemistry] || Evolution of HCV NS3/4a Protease Inhibitors

Liverton, Nigel J.

Year:

2019

Language:

english

File:

PDF, 1.38 MB

english, 2019